🧠 Dihexa: What It Is, How It Works, and Its Potential for Boosting Intelligence

For educational purposes only

What is Dihexa?

Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic peptide derivative of Angiotensin IV. Unlike Ang IV, Dihexa is designed to:

✅ Cross the blood-brain barrier
✅ Be orally bioavailable
✅ Promote cognitive enhancement and neuroprotection in animal studies

🧬 How Does Dihexa Work?

1. HGF/c-Met Activation
   Dihexa binds to hepatocyte growth factor (HGF) and activates its receptor c-Met, which supports neuronal growth and survival (PMC3533412).

2. Synaptogenesis and Neuroplasticity
   It promotes formation of dendritic spines and synapses, crucial for memory and learning – outperforming even BDNF in rodent models.

3. Anti-inflammatory Effects
   Studies show Dihexa reduces neuroinflammation markers such as TNF-α and IL-1β while increasing synaptic proteins like synaptophysin (PMC8615599).

4. PI3K/Akt Pathway Activation
   Its cognitive benefits involve PI3K/Akt signaling, which enhances cell survival and growth (PMC8615599).

🔬 Peer-Reviewed Research on Dihexa

🐭 1. Alzheimer’s Disease Mouse Model

Dihexa restored memory in APP/PS1 mice, improved Morris Water Maze performance, increased synaptic density, and reduced inflammation. Blocking PI3K signaling nullified these effects, showing its critical pathway (PMC8615599).

🐀 2. Scopolamine-Induced Amnesia in Rats

Dihexa reversed cognitive deficits induced by scopolamine, restoring memory to near-normal levels (PMC8916541).

🧠 3. Systematic Review of Ang IV Analogues

A meta-analysis of 32 studies confirmed Ang IV analogues like Dihexa significantly improved cognitive performance in rodents (PubMed 29733881).

⚠️ Human Evidence?

Currently, there are no published human trials on Dihexa. All cognitive-enhancing claims are based on animal studies. Potential cancer risk via c-Met activation and long-term safety remain untested in humans.

🛒 Where to Buy Dihexa

For educational and research purposes only, you can purchase Dihexa from:

🔗 Kimera Chems – Dihexa

💸 Use code: ANDREW for 10% off your order